2021 Meeting – online

Where and when?:

The 6th annual meeting of the Autophagy UK network was held online on 26th and 27th May 2021invited speakers:

  • David Rubinsztein, Cambridge Institute for Medical Research (UK) “Autophagy and neurodegeneration”
  • Tassula Proikas-Cezanne, University of Tuebingen (DE) “Regulation of WIPI1 at the onset of autophagy”
  • Carmine Settembre, TIGEM (IT) “ER-phagy: mechanisms, regulations and functions”

We WERE gratEful for the support of the following sponsors:

MEETING programme:

Day 1

09.15 – 9.30      Welcome and housekeeping: Jon Lane & Berni Carroll

09.30 – 10.15    Tassula Proikas-Cezanne (Tuebingen, Germany): “Regulation of WIPI1 at the onset of autophagy”. Host: Sharon Tooze

10.15 – 11.00    Session 1: Molecules & mechanisms I (Sharon Tooze)

Jo Durgan (Cambridge, UK): “Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine (PS)

Thanh Nguyen (Monash, Australia): “Atg4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system

Lucia Sedlackova (Newcastle, UK): “Autophagy promotes cell and organismal survival by maintaining NAD(H) levels

11:00 – 11:30    Coffee break

11:30 – 12.30    Session 2: Molecules & mechanisms II (Viktor Korolchuk)

Jobert Vargas (London, UK): “NDP52 and TBK1 control the spatiotemporal activation of ULK1 during mitophagy

Dorotea Fracchiolla (Vienna, Austria): “A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy

Agata Makar (Edinburgh, UK): “Distinct lysosomal degradation of autophagic and endocytic cargo

Rachel Curnock (Bristol, UK): “mTORC1-associated lipid homeostasis and cholesterol sensing are perturbed in senescence

13.00 – 15.00    Posters 1

15.00 – 16.00    Session 3: Selective autophagy (David McEwan)

Lea Wilhelm (Dundee, UK): “NIX co-ordinates clearance of mitochondria and peroxisomes

Vinay Eapen (Boston, USA): “Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

Emma Rusilowicz-Jones (Liverpool, UK): “Benchmarking USP30 inhibitors for enhancement of mitophagy and pexophagy

Eliona Tsefou (London, UK): “Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches

16.00 – 16.30    Coffee break

16.30 – 17:30    Plenary lecture: David Rubinzstein: “Autophagy and neurodegenerationHost: Jon Lane

Day 2

09.15 – 9.30    Welcome and housekeeping: Jon Lane & Berni Carroll

09.30 – 10:15    Carmine Settembre: “ER-phagy: mechanisms, regulations & functions”   Host: Berni Carroll

10:15 – 11.00    Session 4: Development/disease (Berni Carroll)

Lisa-Nicole Kiani (London, UK): “Zebrafish model of lysosomal storage disorder CLN2 disease provides a platform for high-throughput drug screening and identifies a hit compound with therapeutic potential

Joanna Moss (Bristol, UK): “Autophagy coordinates chondrocyte development and early joint formation in zebrafish

Ana Lechuga-Vieco (Spain/UK): “Surrogated degradation of cardiomyocyte-derived mitochondria by cardiac macrophages

11:00 – 11:30    Coffee break

11:30 – 12.45    Session 5: Infection/immunity (Rupert Beale)

Oliver Florey (Cambridge, UK): “Bridging the CASM – V-ATPase is a universal regulator of LC3 associated phagocytosis and non-canonical autophagy

Dingxi Zhou (Oxford, UK): “Autophagy-mediated transition of interleukin signalling is crucial to CD4+ T cell proliferation

Pangiotis Tsapras (Warwick, UK): “Selective Autophagy Controls Innate Immune Response through a Tak1/Tab2/Sh3px1 axis

Melanie Krause (London, UK): “Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62

Nora Mellouk (Toronto, Canada): “An ATG16L1-dependent pathway promotes plasma membrane repair and limits pathogen spread

13.00 – 15.00    Posters 2

15:00 – 15:15    Prizes; meeting close: Jon Lane & Berni Carroll


Registration is closed.