Where and when?:
The 6th annual meeting of the Autophagy UK network was held online on 26th and 27th May 2021invited speakers:
- David Rubinsztein, Cambridge Institute for Medical Research (UK) “Autophagy and neurodegeneration”
- Tassula Proikas-Cezanne, University of Tuebingen (DE) “Regulation of WIPI1 at the onset of autophagy”
- Carmine Settembre, TIGEM (IT) “ER-phagy: mechanisms, regulations and functions”
We WERE gratEful for the support of the following sponsors:
MEETING programme:
Day 1
09.15 – 9.30 Welcome and housekeeping: Jon Lane & Berni Carroll
09.30 – 10.15 Tassula Proikas-Cezanne (Tuebingen, Germany): “Regulation of WIPI1 at the onset of autophagy”. Host: Sharon Tooze
10.15 – 11.00 Session 1: Molecules & mechanisms I (Sharon Tooze)
Jo Durgan (Cambridge, UK): “Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine (PS)”
Thanh Nguyen (Monash, Australia): “Atg4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system”
Lucia Sedlackova (Newcastle, UK): “Autophagy promotes cell and organismal survival by maintaining NAD(H) levels”
11:00 – 11:30 Coffee break
11:30 – 12.30 Session 2: Molecules & mechanisms II (Viktor Korolchuk)
Jobert Vargas (London, UK): “NDP52 and TBK1 control the spatiotemporal activation of ULK1 during mitophagy”
Dorotea Fracchiolla (Vienna, Austria): “A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy”
Agata Makar (Edinburgh, UK): “Distinct lysosomal degradation of autophagic and endocytic cargo”
Rachel Curnock (Bristol, UK): “mTORC1-associated lipid homeostasis and cholesterol sensing are perturbed in senescence”
13.00 – 15.00 Posters 1
15.00 – 16.00 Session 3: Selective autophagy (David McEwan)
Lea Wilhelm (Dundee, UK): “NIX co-ordinates clearance of mitochondria and peroxisomes”
Vinay Eapen (Boston, USA): “Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy”
Emma Rusilowicz-Jones (Liverpool, UK): “Benchmarking USP30 inhibitors for enhancement of mitophagy and pexophagy”
Eliona Tsefou (London, UK): “Investigation of USP30 inhibition to enhance Parkin-mediated mitophagy: tools and approaches”
16.00 – 16.30 Coffee break
16.30 – 17:30 Plenary lecture: David Rubinzstein: “Autophagy and neurodegeneration” Host: Jon Lane
Day 2
09.15 – 9.30 Welcome and housekeeping: Jon Lane & Berni Carroll
09.30 – 10:15 Carmine Settembre: “ER-phagy: mechanisms, regulations & functions” Host: Berni Carroll
10:15 – 11.00 Session 4: Development/disease (Berni Carroll)
Lisa-Nicole Kiani (London, UK): “Zebrafish model of lysosomal storage disorder CLN2 disease provides a platform for high-throughput drug screening and identifies a hit compound with therapeutic potential”
Joanna Moss (Bristol, UK): “Autophagy coordinates chondrocyte development and early joint formation in zebrafish”
Ana Lechuga-Vieco (Spain/UK): “Surrogated degradation of cardiomyocyte-derived mitochondria by cardiac macrophages”
11:00 – 11:30 Coffee break
11:30 – 12.45 Session 5: Infection/immunity (Rupert Beale)
Oliver Florey (Cambridge, UK): “Bridging the CASM – V-ATPase is a universal regulator of LC3 associated phagocytosis and non-canonical autophagy”
Dingxi Zhou (Oxford, UK): “Autophagy-mediated transition of interleukin signalling is crucial to CD4+ T cell proliferation”
Pangiotis Tsapras (Warwick, UK): “Selective Autophagy Controls Innate Immune Response through a Tak1/Tab2/Sh3px1 axis”
Melanie Krause (London, UK): “Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62”
Nora Mellouk (Toronto, Canada): “An ATG16L1-dependent pathway promotes plasma membrane repair and limits pathogen spread”
13.00 – 15.00 Posters 2
15:00 – 15:15 Prizes; meeting close: Jon Lane & Berni Carroll
Registration:
Registration is closed.
Autophagy UK Network Meeting 2023 