Autophagy UK Network Meeting 2022
Our 7th annual national meeting for researchers in the field of autophagy was held on 03-04 October 2022 at Scarman, University of Warwick.
Below are the winners of the talks and poster prizes: Keith Boyle, Jake Cross, Wenxin Zhang, George N. Chiduza, Francesco Barone, Natasha Aley. Congratulations all!
Keynote talks 45 min (40 min + 5 min questions)
Top scoring abstract talks: 20 min (15 min + 5 min questions)
Selected talks 15 min (12 min + 3 min questions)
Monday 3rd October 2022
9.30 Registration open, coffee
11.00 Welcome Ioannis Nezis
11.15 Keynote speaker: Sylvie Urbe (University of Liverpool) Regulation of mitophagy and pexophagy by DUBs and E3 ligases
Session 1 – Chair: Bernadette Carroll
12.00 Wenxin Zhang (Francis Crick Institute): Cis-membrane association of human ATG8 proteins N-terminus mediates autophagy
12.15 Keith Boyle (MRC LMB): Conjugation of LC3 to damaged endomembranes upon detection of sphingomyelin exposure by TECPR1.
12.30 Viktor Korolchuk (Newcastle University): Mechanisms of basal mitophagy in human cells
12.50 – 14.30 Lunch, posters and company stands
Session 2 – Chair: Jon Lane
14.30 Thomas McWilliams (University of Helsinki): Metabolism and mitophagy regulation in physiological space and time (Invited speaker)
14.50 Natalia Jimenez-Moreno (University of Edinburgh): Discovery and characterisation of ER-phagy protein networks
15.05 Raksha Gohel (University of Warwick): Characterisation of organellophagy in Drosophila
15.20 Marina Garcia-Macia (The Institute for Biomedical Research of Salamanca) Defective autophagy disrupts neuron metabolism in CLN7 neuronal ceroid lipofuscinosis
15.35– 16.30 Coffee, posters and company stands
WIA coffee break: WIA is a volunteer-run international scientific network founded in 2020 to provide educational opportunities for trainees and early-stage researchers in the field of autophagy and to serve as a leadership platform for women and other under-represented identities. Membership is free and open to all. To join and learn more visit womeninautophagy.com
Session 3 – Chair: Vignir Helgason
16.30 Katharina Lorentzen (University of Dundee) Using nanobodies to manipulate mitophagy
16.45 Brent Ryan (University of Oxford) Integrating animal and human iPSC neuronal models with CRISPRi to understand mitochondrial dysfunction in Parkinson’s disease
17.00 Aina Mogas Barcons (University of Sheffield) Mitophagy abnormalities in parkin mutant Parkinson’s patient-derived neurons and microglia: How do the mitochondrial and lysosomal abnormalities fit in?
17.15 Joe Jones (University of Glasgow) High-throughput validation of pre-clinical ULK1 inhibitors for treatment of autophagy-dependent cancers
17.30 Coffee Break
18.00 Keynote speaker: Patricia Boya (University of Fribourg) – Selective autophagy as a new therapeutic strategy for retinal diseases
Tuesday 4th October 2022
9.15 Keynote speaker: Ian Ganley (University of Dundee) Investigating the interplay between mitophagy and pexophagy
Session 4 – Chair: Simon Wilkinson
10.00 Sovan Sarkar (University of Birmingham) NAD depletion mediates cytotoxicity in human neurons with autophagy deficiency
10.20 Beren Aylan (The Francis Crick Institute) Differential control of cytosolic and phagosomal Mycobacterium tuberculosis replication by ATG7 and ATG14 in human macrophages
10.35 Natasha Aley (LMCB UCL) ATG4B mediates beta-catenin expression and 3D spheroid formation in pancreatic ductal adenocarcinoma
10.50 – 11.45 Coffee, posters and company stands
Session 5 – Chair: Maria Jimenez-Sanchez
11.45 Elena Marcassa (The Francis Crick Institute) CASM activation by SARS-CoV2 Envelope protein
12.00 Jake Cross (Babraham Institute) ATG8 is conjugated directly to damaged lysosomes via non-canonical autophagy/CASM
12.15 Elise Jacquin (Université Paris-Saclay) Interplay between STING and non-canonical autophagy in innate and adaptive immune cells.
12.30 – 14.00 Lunch, posters and company stands
Session 6 – Chair: Michelangelo Campanella
14.00 Madhu Kollareddy (University of Bristol) Human ATG8s stimulate autophagy gene expression through LIR-type binding to the LMX1B transcription factor
14.15 Carmen Figueras Novoa (The Francis Crick Institute) Caspase cleavage of Influenza A virus M2 as a regulator of infection-induced LC3 lipidation
14.30 Muhammed Kocak (The Institute of Cancer Research) Identification of autophagosome composition by proteomics
14.45 Kanchan Phadwal (The Roslin Institute, University of Edinburgh) Dysfunctional mitophagy in arterial calcification – a novel target in cardiovascular diseases.
15.00 Carla Salomo Coll (University of Edinburgh): CCPG1 is a tumour suppressor in pancreatic cancer
15.15: Poster and Best Talk prizes
15.30 Closing remarks (Ioannis Nezis)